Identification and characterization of senescent macrophages in renal allograft rejection: a cross-species MultiOmics study
Our findings identify novel stress-induced SnIMs in renal allograft rejection and highlight their pathogenic role in rejection injury, providing a therapeutic target to improve renal transplant outcome.
Authors
- Qidan Pang
- Hanyu Xiao
- Huyu Wang (ORCID: https://orcid.org/0000-0003-2236-2670)
- Jun Pei (ORCID: https://orcid.org/0000-0001-8261-5903)
- Chunlan Long
- Mingjie Zhang (ORCID: https://orcid.org/0000-0001-9404-0190)
- Yi Hua (ORCID: https://orcid.org/0009-0006-8029-1136)
- Chengjun Yu (ORCID: https://orcid.org/0000-0002-3405-1450)
- Guanghui Wei (ORCID: https://orcid.org/0000-0002-7822-8684)
- Sheng Wen
Institutions
- People's Hospital of Bishan District (CN)
- Chongqing Population and Family Planning Science and Technology Research Institute (CN)
- Chongqing Science and Technology Commission (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1623124
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Medical University
- Centre Scientifique et Technique du Bâtiment