Improper use of TDF/FTC PrEP leading to acute HIV infection with low-level viremia and transient K70KR mutation: diagnostic challenges and drug resistance dynamics
Improper and irregular use of PrEP led to HIV infection in this case. Telemedicine providers should conduct thorough assessments before starting PrEP and offer ongoing adherence support to maximize its effectiveness. This case highlights the importance of using NAT for early HIV detection in PrEP users and suggests including NAT in follow-up assessments to catch PrEP failures early. There is no need for excessive concern regarding the transient drug resistance mutations that may arise following PrEP failure, as these mutations do not compromise the efficacy of HIV treatment.
Authors
- Maohe Yu (ORCID: https://orcid.org/0000-0002-7466-1624)
- Meilin Wang (ORCID: https://orcid.org/0000-0002-8667-2267)
- Tielin Ning (ORCID: https://orcid.org/0000-0002-5351-4879)
- Jun Yao (ORCID: https://orcid.org/0000-0002-3472-1602)
- Pei Liu (ORCID: https://orcid.org/0000-0001-9279-874X)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-8520-1060)
- Cong Jin (ORCID: https://orcid.org/0009-0008-9628-0719)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Tianjin Conservatory of Music (CN)
- Tianjin Centers for Disease Control and Prevention (CN)
- Tianjin Infectious Diseases Hospital (CN)
- National Center for AIDS/STD Control and Prevention,China CDC (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12985-025-02925-1
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Center for Disease Control and Prevention