Salvage sequential integrated boost radiotherapy followed by sintilimab–bevacizumab in cervical small-cell carcinoma with >10 brain metastases: A 3-year survivor case report
The combination of WBRT and SEB improves metastatic dose coverage in CSCC patients with multiple brain metastases. Furthermore, combining immunotherapy with antiangiogenic therapy demonstrates significant efficacy against post-radiation intracranial recurrence, supporting a multimodal individualized approach for further study.
Authors
- Yuanyuan Xu
- Qinglian Wen (ORCID: https://orcid.org/0000-0001-6847-2109)
- Xiangyu Deng (ORCID: https://orcid.org/0000-0002-5027-6975)
- Zhenhua Zhang (ORCID: https://orcid.org/0000-0003-3847-5995)
- Dan Li (ORCID: https://orcid.org/0000-0002-5586-4055)
- Xiang Gong
- Huailin He
Institutions
- Sichuan University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1590848
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00