The role of mitochondria-related key genes in primary biliary cholangitis was analyzed based on transcriptome sequencing data
SHANK2 and TGM2 emerge as key MRGs linking mitochondrial dysfunction with immune dysregulation in PBC and may serve as diagnostic biomarkers and therapeutic targets; further mechanistic and clinical validation is warranted.
Authors
- Runlin Feng (ORCID: https://orcid.org/0000-0002-3532-9450)
- Xuyun Xu
- Lei Zhong (ORCID: https://orcid.org/0000-0002-1901-9698)
- Xiaofan Zhang (ORCID: https://orcid.org/0000-0002-1726-1907)
- Tao Yang (ORCID: https://orcid.org/0000-0002-3691-3819)
- Qihua Shen
Institutions
- Kunming Medical University (CN)
- Kunming Third People's Hospital (CN)
- Huzhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1644682
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00