CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals
Our findings suggest that after accounting for biomarkers of AD pathology, CSF NPTX2 is associated with slower longitudinal atrophy in AD-signature and aging-related regions. These findings are consistent with the view that NPTX2 may be a resilience factor in the presence of pathology and modifies rates of neurodegeneration.
Authors
- Anja Soldan (ORCID: https://orcid.org/0000-0002-6193-0418)
- Yuxin Zhu (ORCID: https://orcid.org/0000-0001-8441-0290)
- Michael I. Miller (ORCID: https://orcid.org/0000-0003-4689-3855)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Corinne Pettigrew
- Guray Erus
- Chan Hyun Na (ORCID: https://orcid.org/0000-0002-3622-2938)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Claire Anderson
- Juan P. Vazquez (ORCID: https://orcid.org/0000-0001-8930-8009)
- Sungtaek Oh (ORCID: https://orcid.org/0000-0002-3786-6372)
- Marilyn Albert
- Paul F. Worley
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1002/acn3.70216
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Institutes of Health
- National Institute of Mental Health