<i>Trichomonas vaginalis</i> Among Cisgender Women Taking Doxycycline Postexposure Prophylaxis
Doxycycline treats and prevents several bacterial and parasitic infections and has been proposed as a possible treatment for Trichomonas vaginalis. Nested in a trial of doxycycline postexposure prophylaxis among cisgender women in Kenya, we conducted a secondary analysis of incident T. vaginalis infections. Among 224 cisgender women randomized to doxycycline postexposure prophylaxis and 225 to standard-of-care, there were 27 T. vaginalis diagnoses in the doxycycline postexposure prophylaxis group and 29 in the standard-of-care group (RR: 0.96, 95% CI: 0.54-1.73, P = .9). Understanding doxycycline postexposure prophylaxis's impact on T. vaginalis remains an important public health question that warrants further investigation.
Authors
- Lauren R. Violette (ORCID: https://orcid.org/0000-0001-6469-7298)
- Jenell Stewart (ORCID: https://orcid.org/0000-0002-8587-1096)
- Elizabeth A. Bukusi (ORCID: https://orcid.org/0000-0002-2031-2808)
- R. Scott McClelland (ORCID: https://orcid.org/0000-0003-2574-4201)
- Felix Mogaka (ORCID: https://orcid.org/0000-0002-7750-0404)
- Jared M. Baeten (ORCID: https://orcid.org/0000-0001-8242-8438)
- Deborah Donnell (ORCID: https://orcid.org/0000-0002-0587-7480)
- Fredericka A. Sesay
- Kevin Oware (ORCID: https://orcid.org/0000-0002-0948-7762)
- Josephine Odoyo (ORCID: https://orcid.org/0000-0003-1749-8645)
- JE Balkus (ORCID: https://orcid.org/0000-0003-2015-4739)
- Victor Omollo (ORCID: https://orcid.org/0000-0002-3457-4876)
Institutions
- University of Minnesota (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Infectious Disease Research Institute (US)
- Public Health – Seattle & King County (US)
- Harvard University (US)
- University of Washington (US)
- University of Minnesota System (US)
- Kenya Medical Research Institute (KE)
- Fred Hutch Cancer Center (US)
- Harvard Pilgrim Health Care (US)
- Hennepin Healthcare Research Institute (US)
- Seattle University (US)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1093/infdis/jiaf519
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00