Osmotic Demyelination Syndrome in a Patient With Schizophrenia: A Case Report

This case highlights ODS as a rare but critical differential diagnosis for severe EPS in schizophrenia, particularly when presenting with lead-pipe rigidity and pseudobulbar palsy. Greater awareness of this presentation can facilitate timely diagnosis and appropriate management, avoiding misattribution to antipsychotic-induced side effects that may result in long-term morbidity or mortality.

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Publication Details

Journal
Neuropsychopharmacology Reports
Published
2025-10-09
DOI
https://doi.org/10.1002/npr2.70065
Primary Topic
Electrolyte and hormonal disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Osmotic Demyelination Syndrome in a Patient With Schizophrenia: A Case Report

Chen‐Chia Lan, Yin‐Chen Lai
Neuropsychopharmacology Reports
Electrolyte and hormonal disorders
article

Osmotic Demyelination Syndrome in a Patient With Schizophrenia: A Case Report

Chen‐Chia Lan, Yin‐Chen Lai
article en

Abstract

This case highlights ODS as a rare but critical differential diagnosis for severe EPS in schizophrenia, particularly when presenting with lead-pipe rigidity and pseudobulbar palsy. Greater awareness of this presentation can facilitate timely diagnosis and appropriate management, avoiding misattribution to antipsychotic-induced side effects that may result in long-term morbidity or mortality.

Neuropsychopharmacology ReportsVol. 45(4)
Taichung Veterans General Hospital (TW)
Openalex Percentile: Top 59%
Electrolyte and hormonal disorders
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Osmotic Demyelination Syndrome in a Patient With Schizophrenia: A Case Report — Chen‐Chia Lan, Yin‐Chen Lai · Neuropsychopharmacology Reports (2025) | TGRS Research Map | TGRS