Dynamic deuterium metabolic imaging in glioblastoma at 7T
Dynamic DMI at 7 T reveals metabolic alterations in GBM, particularly through the <sup>2</sup>H-Lac/<sup>2</sup>H-Glx ratio. This contrast was primarily driven by decreased <sup>2</sup>H-Glx rather than profoundly increased <sup>2</sup>H-Lac. These findings support the utility of DMI in assessing metabolic reprogramming in brain tumors.
Authors
- Dennis W. J. Klomp (ORCID: https://orcid.org/0000-0002-5884-5386)
- Jeanine J. Prompers (ORCID: https://orcid.org/0000-0002-4756-4474)
- Mark Gosselink (ORCID: https://orcid.org/0000-0003-1578-3696)
- Dimitri Welting
- Pieter van Eijsden (ORCID: https://orcid.org/0000-0002-8935-140X)
- Tom J. Snijders (ORCID: https://orcid.org/0000-0003-0857-081X)
- Evita Wiegers (ORCID: https://orcid.org/0000-0001-5451-2990)
- Kiki Tesselaar (ORCID: https://orcid.org/0000-0002-9847-0814)
- Narjes Ahmadian (ORCID: https://orcid.org/0009-0004-2072-031X)
- Sigrid A. Otto
Institutions
- Utrecht University (NL)
- Heidelberg University (DE)
- Maastricht University Medical Centre (NL)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
Publication Details
- Journal
- Magnetic Resonance Materials in Physics Biology and Medicine
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1007/s10334-025-01299-3
- Citations
- 2
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek