<scp> <i>CDKN2A</i> </scp> deletion in p16‐negative/ <scp>HPV</scp> ‐positive head and neck squamous cell carcinoma: Highlighting the molecular basis behind the limitation of relying on p16 immunohistochemistry as a surrogate marker for <scp>HPV</scp
This series highlights the genomic basis for the 'false' negative p16 results, raising awareness of a significant diagnostic pitfall while emphasizing the importance of careful consideration of clinicopathologic parameters in the clinical workup of these cases.
Authors
- Yen Chen Kevin Ko (ORCID: https://orcid.org/0000-0001-6081-5971)
- Mary Shago (ORCID: https://orcid.org/0000-0002-7386-2504)
- Rong Hu (ORCID: https://orcid.org/0000-0002-1502-9848)
- Raja R. Seethala (ORCID: https://orcid.org/0000-0003-3617-075X)
- Bibianna Purgina (ORCID: https://orcid.org/0000-0003-0268-8278)
- Anita Nagy (ORCID: https://orcid.org/0000-0002-2904-0618)
- Hezhen Ren (ORCID: https://orcid.org/0000-0002-2779-7297)
- Elan Hahn (ORCID: https://orcid.org/0000-0003-0685-7614)
- Trevor Teich (ORCID: https://orcid.org/0000-0003-2355-8341)
Institutions
- University of British Columbia (CA)
- University of Ottawa (CA)
- University of Toronto (CA)
- UW Health University Hospital (US)
- Ottawa Hospital (CA)
- Hospital for Sick Children (CA)
- Sinai Health System (CA)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Histopathology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1111/his.70021
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85