Molecular profile of atypical Leydig cell tumours
CNVs by themselves are not sufficient to discriminate between cases that are benign versus those with malignant potential, without the use of histomorphological parameters. Genomic instability was only detected in the malignant and atypical cases, and not in any of the benign tumours. Thus, genomic instability may represent an early step in malignant progression. The presence of metastasis remains the only malignant criterion for LCTs.
Authors
- Muhammad Choudhry (ORCID: https://orcid.org/0000-0002-5784-0823)
- Bob Argiropoulos (ORCID: https://orcid.org/0000-0001-9638-9126)
- Fadi Brimo (ORCID: https://orcid.org/0000-0002-7589-0453)
- Yaser Gamallat (ORCID: https://orcid.org/0000-0001-9980-2107)
- Aslı Yilmaz (ORCID: https://orcid.org/0000-0003-4148-8316)
- Diogo Caires
- Tarek A. Bismar
Institutions
- University of Calgary (CA)
- McGill University Health Centre (CA)
Publication Details
- Journal
- Histopathology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1111/his.70018
- Primary Topic
- Testicular diseases and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00