Elevated LL-37/FPR2 Axis and its Regulatory Role for Gingival Fibroblasts in Periodontitis
We found that the co-upregulation of LL-37/FPR2 in periodontitis-affected gingival tissues, positively correlates with clinical parameters (PD/CAL). These findings provide new insights into the dual role of LL-37 in periodontal inflammation and suggest novel strategies for targeted therapy by selectively inhibiting high-concentration LL-37/FPR2 signaling.
Authors
- Shucheng Hu (ORCID: https://orcid.org/0009-0005-6585-3017)
- Weijun Yu (ORCID: https://orcid.org/0000-0003-3121-5453)
- Yuanjie Shi
- Tingting Lin (ORCID: https://orcid.org/0000-0001-5474-4070)
- Bin Jiang (ORCID: https://orcid.org/0000-0003-3775-284X)
- Eryi Lu (ORCID: https://orcid.org/0000-0002-0045-2571)
- Yuting Gu (ORCID: https://orcid.org/0000-0001-5891-0101)
- Min Jin (ORCID: https://orcid.org/0000-0003-0073-4816)
- Yue Shen (ORCID: https://orcid.org/0000-0002-4148-6874)
- Zhurong Cui
- Ruhan Yang
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.identj.2025.103943
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00