An in vivo PET/CT investigation of mitochondrial complex 1, sigma 1, and synaptic vesicle 2 A in patients with amyotrophic lateral sclerosis
Our findings reveal loss of MC1 and S1R in ALS, suggesting mitochondrial dysfunction associated with disease progression. This work provides initial insights of mitochondrial and receptor pathology in ALS, potentially guiding future biomarker development and therapeutic interventions.
Authors
- Pegah Khosropanah (ORCID: https://orcid.org/0000-0002-5255-7631)
- Heather Wilson (ORCID: https://orcid.org/0000-0002-2225-0241)
- Eugenii A. Rabiner (ORCID: https://orcid.org/0000-0003-3612-6687)
- Graham Searle
- Marios Politis (ORCID: https://orcid.org/0000-0001-8530-7113)
- Edoardo Rosario de Natale (ORCID: https://orcid.org/0000-0002-9708-9886)
- Robert A. Comley (ORCID: https://orcid.org/0000-0001-7546-5492)
- Alana Terry
- Luca Passamonti (ORCID: https://orcid.org/0000-0002-7937-0615)
- Hideo Tsukada (ORCID: https://orcid.org/0000-0002-8574-293X)
- Jan Passchier (ORCID: https://orcid.org/0000-0003-1958-7748)
- Alex Whittington
- Joji Philip Verghese (ORCID: https://orcid.org/0000-0002-6651-9994)
- Roger N. Gunn (ORCID: https://orcid.org/0000-0003-1181-5769)
- Holly Wright (ORCID: https://orcid.org/0000-0001-5218-011X)
- Karleyton C. Evans
- Ekaterina Pererva
Institutions
- Biogen (United States) (US)
- Hamamatsu Photonics (Japan) (JP)
- University of Exeter (GB)
- Hammersmith Hospital (GB)
- AbbVie (United States) (US)
- MRC Brain Network Dynamics Unit (GB)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.nbd.2025.107138
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00