Significances Of Radio-Isotope Imaging Relevant To Management Of Long Bone Sarcomas

Introduction: Osteosarcomas (OS) and Ewing’s sarcomas (ES) are third most common cancer in young adult group, lymphomas and brain tumors being more prevalent. Aim: The study aims to give appropriate measurements for making prosthesis with the use of Bone scan, MRI scan and Digital radiographs to lead better quality of remaining part of their life. Materials & Methods: Patients with malignant bone tumor of Osteosarcoma and Ewing’s sarcoma of lower/upper limbs enrolled from July 2019 to August 2023 at the Institute were taken up for the prospective study. From 122 patients we have divided into two groups, Pre chemo studies and Pre and post chemo studies and each group consists of 122 and 83 patients. Totally, around 205 patients were eligible for this study and Tc99m MDP bone scan, MRI scan and Digital Radiography were taken for all these patients. Statistical Analysis: Measures of central tendency and deviation were employed to describe the data as tables (Mean, SD, median, range, %difference, etc.) and graphs (boxplots, etc.) Results: In Pre chemo study, was carried out involving 122 patients, which included 77 males and 45 females and p value < 0.001 and 90% cut off percent change value is 18.3% for pre chemo bone scan and HPE values. Pre chemo & Post chemo study, was carried out involving 84 patients, which included 51 males and 33 females and p value < 0.087 and 90% cut off percent change value is almost equal for pre chemo MRI scan and HPE values Conclusion: Pre chemo study concluded that pre chemo bone scan, MRI scan and Digital radiography measurements are comparable and statistically analyzed using paired t test. Post chemo Bone scan tumor length variation only 8.2% and MRI scan measurements are almost equal when compare to post-operative tumor measurements. Keywords: LSS, MRI, DR, OS, ES, NAC & AC