Frontiers in LONP1 research: Unraveling molecular mechanisms, disease associations, and therapeutic strategies
LONP1 is a conserved mitochondrial AAA+ protease central to mitochondrial proteostasis. This review summarizes its structural features, protease-chaperone functions, and roles in metabolic regulation (heme/sulfur/steroid pathways) and disease. In cancer, LONP1 overexpression drives tumor progression via metabolic reprogramming, EMT induction, metastasis, and therapy resistance, establishing it as a pan-cancer therapeutic target. Inhibitors face delivery and selectivity challenges, prompting future strategies like mitochondrial-targeted delivery and allosteric modulators. Research directions include mechanistic studies and clinical translation for cancer and neurodegenerative disorders.
Authors
- Yi Rong Su (ORCID: https://orcid.org/0000-0002-3132-0707)
- Yangguang Ou (ORCID: https://orcid.org/0000-0002-6902-3978)
- Bin Lü (ORCID: https://orcid.org/0000-0001-9300-4542)
- Shuyi Wang (ORCID: https://orcid.org/0000-0002-0868-8378)
- Zhiyan Zhang (ORCID: https://orcid.org/0000-0002-2387-8735)
- W. Xi
Institutions
- University of South China (CN)
Publication Details
- Journal
- Mitochondrial Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.mitoco.2025.10.001
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00