Acquired skin-pulmonary syndromes

Lesions of the skin and its appendages against the background of respiratory diseases are fairly common in routine clinical practice. Abnormal changes in the skin and its appendages can manifest as signs of a multisystem genetic disease, chronic lung diseases, or acquired syndromes with combined lesions of the skin, its appendages, and respiratory organs. Abnormal changes in the skin and its appendages against the background of respiratory diseases can be linked to a severe systemic condition (Bazex syndrome, granulomatosis with polyangiitis, Löfgren’s syndrome), but at the same time can be the only clinical sign of the disease (yellow nail syndrome). The aim of this work is to describe the clinical features of acquired skin-pulmonary syndromes, including Bazex syndrome, granulomatosis with polyangiitis, Löfgren’s syndrome, yellow nail syndrome, eosinophilic granulomatosis with polyangiitis, and Sjogren syndrome, with an emphasis on the known clinical manifestations in the skin, its appendages and respiratory organs. Conclusion. Identification of distinct symptoms and syndromic nature of a specific disease is a very complex task, requiring deep academic and clinical knowledge of the physician. The variety of clinical lesions of the skin, its appendages, and respiratory organs associated with skin-pulmonary syndromes may create challenges during a routine appointment. In this article, the authors attempted to describe the main acquired skin-pulmonary syndromes encountered in the routine practice of both a pulmonologist and a dermatologist, with an emphasis on the clinical manifestations of these syndromes in the skin, its appendages, and respiratory organs.