Rare case of lung involvement in a patient with adult Still’s disease

Adult-onset Still’s disease (AOSD) is a rare polygenic systemic autoinflammatory disease of unknown etiology, characterized by neutrophilic leukocytosis and the absence of rheumatoid factor and antibodies to cyclic citrulline-containing peptide in the blood serum. Lung damage in AOSD is a rare but serious complication. Bronchiolitis, bronchitis, nonspecific interstitial pneumonia, and organizing interstitial pneumonia have been described as patterns of lung damage in AOSD. Pulmonary manifestations of AOSD remain poorly understood. The aim of the article was to demonstrate a clinical case of AOSD, the main manifestation of which was the development of cryptogenic organizing pneumonia with respiratory failure. The article presents in detail the stages of the diagnostic search. An interesting feature of this clinical case was the absence of the most common symptoms of AOSD (sore throat, arthritis/arthralgia). Conclusion. This clinical case emphasizes the importance of clinicians’ awareness of possible pulmonary complications in AOSD.

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Publication Details

Journal
PULMONOLOGIYA
Published
2025-10-09
DOI
https://doi.org/10.18093/0869-0189-2025-35-5-732-738
Primary Topic
Autoimmune and Inflammatory Disorders Research
Type
article
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article

Rare case of lung involvement in a patient with adult Still’s disease

А. В. Кривоногов, O. V. Teplyakova, И. В. Лещенко, Olga Tsvetkova et al.
PULMONOLOGIYA
Autoimmune and Inflammatory Disorders Research
article

Rare case of lung involvement in a patient with adult Still’s disease

А. В. Кривоногов, O. V. Teplyakova, И. В. Лещенко, Olga Tsvetkova, Yu. E. Batrudinova, E. Z. Eidlina, S. M. Chapurina
article en

Abstract

Adult-onset Still’s disease (AOSD) is a rare polygenic systemic autoinflammatory disease of unknown etiology, characterized by neutrophilic leukocytosis and the absence of rheumatoid factor and antibodies to cyclic citrulline-containing peptide in the blood serum. Lung damage in AOSD is a rare but serious complication. Bronchiolitis, bronchitis, nonspecific interstitial pneumonia, and organizing interstitial pneumonia have been described as patterns of lung damage in AOSD. Pulmonary manifestations of AOSD remain poorly understood. The aim of the article was to demonstrate a clinical case of AOSD, the main manifestation of which was the development of cryptogenic organizing pneumonia with respiratory failure. The article presents in detail the stages of the diagnostic search. An interesting feature of this clinical case was the absence of the most common symptoms of AOSD (sore throat, arthritis/arthralgia). Conclusion. This clinical case emphasizes the importance of clinicians’ awareness of possible pulmonary complications in AOSD.

PULMONOLOGIYAVol. 35(5)
Ural State Medical University (RU), Ural research Institute of Phthisiopulmonology (RU), Novay (NL)
Openalex Percentile: Top 64%
Autoimmune and Inflammatory Disorders Research
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Rare case of lung involvement in a patient with adult Still’s disease — А. В. Кривоногов, O. V. Teplyakova, et al. · PULMONOLOGIYA (2025) | TGRS Research Map | TGRS