Risk of Clostridioides difficile Infection After Helicobacter pylori Treatment in a Large Population in the United States

In a large, diverse, community-based population, treatment of <i>H pylori</i> was associated with an increased risk of CDI, although the overall incidence was very low. History of IBD and prior CDI were the strongest predictors of CDI. These findings support the safety of <i>H pylori</i> treatment, although caution should be exercised when treating <i>H pylori</i> among individuals with IBD or a prior history of CDI.