Stress-Induced Dysregulation of the Guidance Cue Receptor DCC Alters Corticolimbic Circuit Architecture
DCC receptors may influence susceptibility or resilience to social stress-induced depression-like behaviors by altering the apical dendritic architecture of PFC pyramidal neurons, particularly those projecting to the nucleus accumbens shell. This mechanism may be at play in the neurobiology of depression, pointing to DCC receptors as promising therapeutic targets.
Authors
- Cecilia Flores (ORCID: https://orcid.org/0000-0001-8606-5910)
- François M. Abboud (ORCID: https://orcid.org/0009-0005-9232-783X)
- Giovanni Hernández (ORCID: https://orcid.org/0000-0001-9719-6027)
- Ashraf Mahmud (ORCID: https://orcid.org/0009-0009-4191-8639)
Institutions
- Douglas Mental Health University Institute (CA)
- McGill University (CA)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100629
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91