Efficacy of luseogliflozin for renal function preservation in patients with type 2 diabetes mellitus and impaired renal function: A randomized open‐label clinical trial ( <scp>RESOLUTION</scp> study)
Although the primary endpoint did not reach statistical significance, luseogliflozin may provide renoprotective benefits in patients with type 2 diabetes mellitus and moderate-to-severe renal impairment, potentially by slowing eGFRcreat decline post-initial decline.
Authors
- Yosuke Okada
- Atsushi Nakagawa (ORCID: https://orcid.org/0000-0002-1700-7861)
- Yutaka Wakasa
- Shinji Kume (ORCID: https://orcid.org/0000-0001-6937-9715)
- Hiroaki Satoh (ORCID: https://orcid.org/0000-0002-0353-5807)
- Takehiro Kato (ORCID: https://orcid.org/0000-0003-3236-2463)
- Toshinari Takamura (ORCID: https://orcid.org/0000-0002-4393-3244)
- Masao Toyoda (ORCID: https://orcid.org/0000-0003-4142-1218)
- Satoshi Miyamoto (ORCID: https://orcid.org/0000-0002-9056-6395)
- Mari Kitada
- Masaji Miyamoto
- Yasushi Ômura
- Hiroshi Arima (ORCID: https://orcid.org/0000-0003-3746-1997)
- Shin‐ichi Araki (ORCID: https://orcid.org/0000-0002-2933-0316)
- Takeshi Onoue (ORCID: https://orcid.org/0000-0002-8589-9937)
- Akimichi Asano
- Daisuke Yabe (ORCID: https://orcid.org/0000-0002-5334-7687)
- Osamu Sekine
- Kenichi Tanaka (ORCID: https://orcid.org/0000-0003-3538-3163)
- Hideki Kamiya (ORCID: https://orcid.org/0000-0003-3197-2542)
- Daisuke Suzuki (ORCID: https://orcid.org/0000-0001-7365-0854)
- Hideki Nishimura
- Yoshikata Morita
- Tomohiko Ito
- Motohide Isono
Institutions
- Kanazawa University (JP)
- Tokai University (JP)
- Suzuki (Japan) (JP)
- Shiga University of Medical Science (JP)
- Aichi Medical University (JP)
- Kanazawa Medical University (JP)
- University of Occupational and Environmental Health Japan (JP)
- Wakayama Medical University (JP)
- Taoka Hospital (JP)
- Kanazawa Medical Center (JP)
- Fukuoka University Hospital (JP)
- Shiga University of Medical Science Hospital (JP)
- Okayama University Hospital (JP)
- Kawamura Hospital (JP)
- Ishikawa Prefectural Central Hospital (JP)
- Koga Hospital (JP)
- Kanazawa Medical University Hospital (JP)
- Keiju Medical Center (JP)
- Juntendo University Urayasu Hospital (JP)
- Nagahama City Hospital (JP)
- Shiga Medical Center (JP)
- Gifu University (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1111/jdi.70173
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kanazawa University
- Kanazawa Medical University