Genome‐Wide Blood <scp>DNA</scp> Methylation Profiling in Birch Pollen Allergic Patients Undergoing Allergen‐Specific Immunotherapy
GCNT2 and ABRA are implicated in Rho-signaling, a pathway involved in Th2 differentiation. GCNT2 modulates the SMAD-dependent TGF-β pathway, indicating a role in mediating AIT-induced immunotolerance. This is the first longitudinal study investigating DNA methylation changes induced by birch pollen AIT.
Authors
- Angelika Lahnsteiner (ORCID: https://orcid.org/0000-0001-7402-3369)
- Lorenz Aglas (ORCID: https://orcid.org/0000-0002-1236-5934)
- Angela Risch (ORCID: https://orcid.org/0000-0002-8026-5505)
- Ronald van Ree (ORCID: https://orcid.org/0000-0003-0767-0894)
- Carsten Bindslev‐Jensen (ORCID: https://orcid.org/0000-0002-8940-038X)
- Mengzhen Hao (ORCID: https://orcid.org/0000-0002-5363-191X)
- Serge A. Versteeg (ORCID: https://orcid.org/0000-0002-9729-3000)
- Line Kring Tannert (ORCID: https://orcid.org/0000-0003-4039-5708)
- Victoria Ellmer
Institutions
- University of Salzburg (AT)
- Odense University Hospital (DK)
- Amsterdam University Medical Centers (NL)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Allergy
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1111/all.70094
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- China Scholarship Council
- Universität Salzburg
- Bundesministerium für Bildung, Wissenschaft und Forschung