Elucidating biomarkers of carcinogenesis in ulcerative colitis: insight from Mendelian randomization and transcriptomics
Genetic susceptibility to UC significantly correlated with an increased risk of CRC. BATF and JDP2 emerged as key biomarkers in the carcinogenesis of UC. Based on abnormal BATF expression at the single-cell level, Treg cell was identified as important cell involved in UC carcinogenesis.
Authors
- Xiang Xiao (ORCID: https://orcid.org/0000-0002-4381-9273)
- Yi Cai (ORCID: https://orcid.org/0000-0001-7773-2064)
- Xuanyu Wu (ORCID: https://orcid.org/0009-0009-8607-9381)
- Tian Liu
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1007/s12672-025-02608-x
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00