Functional characterization of lactate metabolism and its key regulatory genes reveals lactate-mediated modulation of carbon and nitrogen metabolism in Phaeodactylum tricornutum
Lactate metabolism and lactylation metabolic processes mediated by LDHA, GLO1, GLO2 and D-LCR are important mechanisms by which lactate affects the growth of P. tricornutum, rapidly regulates carbon and nitrogen metabolism processes, and promotes the accumulation of lipids under LN conditions.
Authors
- Jiawen Duan
- Xiaoni Cai
- Aiyou Huang
- Wei Ren (ORCID: https://orcid.org/0000-0001-8070-8524)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-6812-7356)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-9861-4681)
- Long Hao (ORCID: https://orcid.org/0000-0001-5326-784X)
- Chenhui Li (ORCID: https://orcid.org/0000-0003-3158-9869)
- Zhenyu Xie (ORCID: https://orcid.org/0000-0002-7926-4927)
- Yanhua Zeng (ORCID: https://orcid.org/0000-0002-1330-456X)
- Yimeng Zheng
Institutions
- Guangxi Medical University (CN)
- Hainan University (CN)
- Coconut Research Institute (CN)
- Guangxi Academy of Agricultural Science (CN)
- Guangxi Academy of Sciences (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12934-025-02779-w
- Citations
- 1
- Primary Topic
- Marine and coastal ecosystems
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- National Natural Science Foundation of China
- Hainan University