Role of OAF and Smoking Initiation in COPD Risk: Insights from Mendelian Randomization
The MR results suggest that OAF may be a genetic risk factor for COPD, with immune cell phenotypes, particularly CD14-CD16-AC, potentially playing a mediating role in COPD development. Smoking initiation is also positively correlated with COPD, playing an important role in its pathogenesis.
Authors
- Siwen Chen
- Feng You
- Bianjin Sun (ORCID: https://orcid.org/0000-0001-7717-7419)
- G Chen
- Kai Xu
- Qiheng Yuan
Institutions
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Wenzhou City People's Hospital (CN)
Publication Details
- Journal
- Tobacco Induced Diseases
- Published
- 2025-10-09
- DOI
- https://doi.org/10.18332/tid/210379
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00