Development of vismodegib-loaded PLGA nanoparticles for the treatment of pancreatic cancer: formulation and <i>in vitro</i> assessment in co-culture monolayers and spheroids
Sequential treatment with vismodegib-loaded PLGA nanoparticles enhanced gemcitabine toxicity by prolonging growth inhibition and further inducing apoptosis in a 3D pancreatic spheroid model.
Authors
- M. Zhang
- Wafa’ T. Al-Jamal (ORCID: https://orcid.org/0000-0001-8671-6533)
- Ubah Abdi
Institutions
- Queen's University Belfast (GB)
Publication Details
- Journal
- RSC Pharmaceutics
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1039/d5pm00161g
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Wolverhampton
- Guizhou Medical University