The integration of single-cell and metabolomics reveals the increase of oxidative phosphorylation during the liver metastasis of colorectal cancer
This study identifies OXPHOS upregulation as a key metabolic alteration during CRC liver metastasis, which could be induced by TGFβ signaling pathway. These findings contribute to a refined understanding of CRC metabolic adaptation in liver metastases and may inform therapeutic strategies targeting OXPHOS in advanced CRC.
Authors
- Sizheng Sun
- Yi‐Cheng Huang (ORCID: https://orcid.org/0000-0002-4076-1360)
- Fanggui Xu
- Zhengxia Liu (ORCID: https://orcid.org/0000-0002-2132-6064)
- Wenyuan Li (ORCID: https://orcid.org/0000-0003-2914-684X)
- Tianyu Liu (ORCID: https://orcid.org/0000-0002-1507-3793)
- Lu Chen (ORCID: https://orcid.org/0000-0002-3797-3872)
- Xiagang Luo (ORCID: https://orcid.org/0000-0002-7674-7958)
- Chunzhao Yu (ORCID: https://orcid.org/0000-0002-7612-3491)
- E. Yiming
Institutions
- Nantong University (CN)
- Zhongda Hospital Southeast University (CN)
- Suzhou Municipal Hospital (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s40170-025-00408-z
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Jiangsu Provincial Key Research and Development Program
- National Key Research and Development Program of China