P2RX4 promotes hepatocellular carcinoma progression via calcium-mediated PI3K/AKT activation and immune remodeling
P2RX4 may facilitate HCC progression by augmenting calcium influx, activating the PI3K/AKT pathway, and diminishing anti-tumor immunity. It may function as a biomarker and therapeutic target in HCC. Additional, in vivo investigations are required to validate these findings.
Authors
- Ze Niu (ORCID: https://orcid.org/0000-0001-7675-7235)
- Yanmei Gu (ORCID: https://orcid.org/0000-0001-8932-8886)
- Futian Tang
- Jianrong Wang (ORCID: https://orcid.org/0000-0001-8180-5174)
- Yumin Li (ORCID: https://orcid.org/0000-0002-9267-1412)
Institutions
- Gansu Agricultural University (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12957-025-04023-6
- Citations
- 2
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.24