Visible‐Light‐Induced Controlled C–H Cyanation or Thiocyanation of Indolizines
An efficient and controlled approach for C–H cyanation/thiocyanation of indolizines is reported under visible‐light‐induced conditions. NH 4 SCN is used as the cyano or thiocyano source and the presence or absence of H 2 O 2 are found to be the key factor in the selective construction of C‐3 cyano or thiocyano indolizines. A set of control experiments, such as radical trapping experiments and fluorescence quenching studies are conducted to assess mechanistic insights of the reaction.
Authors
- Liu Ju-bin
- Qichao Yang (ORCID: https://orcid.org/0000-0003-2275-5386)
- Hua Cao (ORCID: https://orcid.org/0000-0001-8825-0175)
- Yuhao Jiang (ORCID: https://orcid.org/0009-0004-9436-7109)
- Yue Yu (ORCID: https://orcid.org/0000-0002-0807-8713)
- Dongxin Lin (ORCID: https://orcid.org/0000-0002-8723-8868)
Institutions
- Guangdong Pharmaceutical University (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1002/adsc.70140
- Citations
- 2
- Primary Topic
- Synthesis and Reactivity of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 1.87