Mitochondria-targeting polymer cLipG/CuET activates the cGAS/STING pathway to enhance cholangiocarcinoma immunotherapy
With a high biosafety, cLipG/CuET exerted a synergistic effect on the immune checkpoint inhibitor αCTLA-4 against ICC, and their combination provided a new therapeutic strategy.
Authors
- Jingjing Wei (ORCID: https://orcid.org/0000-0002-2197-8062)
- Hong‐Wen Liu (ORCID: https://orcid.org/0000-0001-8757-1620)
- Yu Liu (ORCID: https://orcid.org/0000-0002-1806-6011)
- Yani Pan (ORCID: https://orcid.org/0000-0002-4755-9878)
- Ge Bai (ORCID: https://orcid.org/0000-0002-2878-1772)
- Zhangding Wang (ORCID: https://orcid.org/0000-0002-3959-4542)
- Yue Zhou (ORCID: https://orcid.org/0000-0002-1335-5703)
- Lei Wang (ORCID: https://orcid.org/0000-0001-8172-5334)
- Wei Li (ORCID: https://orcid.org/0000-0002-4264-1864)
- Lei Xu (ORCID: https://orcid.org/0009-0004-1374-2211)
- Nannan Zhang
- Sijia Chen (ORCID: https://orcid.org/0000-0002-8464-5003)
- Yun Zhu
- Xin Fu (ORCID: https://orcid.org/0000-0001-9726-9388)
- Qi Chen
- Yu‐Guang Zhou (ORCID: https://orcid.org/0000-0001-5887-9781)
- Lishan Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s12951-025-03689-0
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59