Circulating memory B-cell receptor repertoire analysis identifies novel candidate antibodies against metastatic melanoma in immunotherapy-responsive patients
Although our study is based on a limited number of individuals, our observations indicate that it may be possible to further investigate the human response to immunotherapy for the identification of rare mature B clonotypes targeting plasma membrane antigens on tumor cells. These preliminary findings could contribute to the future development of fully human-compatible immunotherapies, pending additional validation and <i>in vivo</i> studies.
Authors
- Valentina Ancarani (ORCID: https://orcid.org/0000-0001-7571-8605)
- Francesco Limarzi (ORCID: https://orcid.org/0000-0002-1367-3525)
- Matteo Zurlo (ORCID: https://orcid.org/0000-0002-6131-3727)
- Federica Marocchi (ORCID: https://orcid.org/0000-0002-5610-5499)
- Massimiliano Mazza (ORCID: https://orcid.org/0000-0001-9053-5743)
- Anna De Lucia (ORCID: https://orcid.org/0000-0002-3128-9738)
- Anna Gaimari (ORCID: https://orcid.org/0000-0002-7456-4197)
- Davide Angeli (ORCID: https://orcid.org/0000-0002-8855-0829)
- Massimo Guidoboni (ORCID: https://orcid.org/0000-0001-7703-790X)
- Luigi Pasini (ORCID: https://orcid.org/0000-0002-1762-6531)
- Luisa Lanfrancone (ORCID: https://orcid.org/0000-0002-4523-3815)
- Roberta Maltoni (ORCID: https://orcid.org/0000-0003-0366-792X)
- Sara Bravaccini (ORCID: https://orcid.org/0000-0002-0075-8538)
- Patricia Borges de Souza (ORCID: https://orcid.org/0000-0001-6862-8302)
- Fabio Nicolini (ORCID: https://orcid.org/0000-0001-6846-5435)
- Laura Ridolfi (ORCID: https://orcid.org/0000-0003-1870-3380)
- Maria Maddalena Tumedei (ORCID: https://orcid.org/0000-0003-3105-9796)
- C Magnoni
- Claudio Cerchione (ORCID: https://orcid.org/0000-0002-9104-5436)
- Lucia Mazzotti (ORCID: https://orcid.org/0000-0002-1253-8823)
- Sara Capobianco
- Luca Gazzola
- Miriana Ghirelli
Institutions
- University of Ferrara (IT)
- Università degli Studi di Enna Kore (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Azienda Unità Sanitaria Locale Della Romagna (IT)
- Ospedale G.B. Morgagni - L.Pierantoni (IT)
- European Institute of Oncology (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1636722
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Fondazione Umberto Veronesi