Nonsurgical Management of Sinonasal Teratocarcinosarcoma With Chemoradiotherapy: A Case Report

Sinonasal teratocarcinosarcoma (SNTCS) is a rare, aggressive malignancy with epithelial, mesenchymal, and neuroectodermal components. We report the case of a 66-year-old man with right nasal obstruction and epistaxis. Imaging revealed a mass in the right nasal cavity and ethmoid sinus. Histopathology revealed immature squamous nests with clear cytoplasm, and immunohistochemistry confirmed multiphenotypic differentiation. Therefore, SNTCS was diagnosed. Owing to inoperability, the patient underwent chemoradiotherapy, which resulted in stable disease at 6 months. This case highlights the diagnostic complexity of SNTCS and suggests that nonsurgical management may be effective in select cases.