Investigation the effect of administration different levels of Licorice extract on cutaneous skin wound healing in New-Zealand rabbits

The aim of the current study wad to determine the effect of use different levels of licorice extract on New-Zealand rabbits cutaneous skin wounds healing. Material and methods: Twenty-one adult male rabbits by average age, 12 months and average weight of 3.5±0.750 kg were selected to evaluate cutaneous wound healing after treatment with 100, 200 and 300 mg/kg of licorice extract. Experimental wound excision model in rabbits was created by means of a skin punch of 2 cm diameter. The experimental rabbits were topically treated for seventeen days with a saline control or decoctions of mixed with common thistle and thyme derived extracts with carboxymethyl cellulose. The centripetal retraction, clinical, and histological aspects of the wounds were observed until complete wound healing. Result: The phototherapeutics agent presents in licorice extract improved cicatrization of cutaneous lesions in rabbit’s skin during the first days of treatment. The treatments were beneficial to the reparation process of wound healing. The result showed that the administration the licorice extract has beneficial effects in the inflammatory phase and on the reparation process in experimental animal. Administration of 150 mg of licorice extract showed a good effectiveness on the macroscopic aspect of cutaneous lesions in rabbits but only during the first treatment days. Conclusion: In conclusion we may note that the use of different levels of licorice extract may have improved fibroplasia and pytotherapeutic activities and could be useful in topical treatment of cutaneous lesions in New-Zealand male adult rabbits without adverse effects.