Innovative methods in evaluating the effects of lipid-lowering medication on bone tissue

The benefic effects of lipid-lowering medication, in terms of reducing cardiovascular risk, should not to lead to ignoring of the potential adverse effects of this medication. Methods. The study used two quantitative, modern methods for analyzing bone tissue: 1D ¹H NMR diffusiometry and 2D T₂-T₂ exchange ¹H NMR relaxometry. The effects of simvastatin and fenofibrate on the Albinos Wistar rats' bone tissue cytoarchitecture have been highlighted, both in terms of pore size and pore connectivity. The evaluations were dynamical, at 14, 16, and 18 weeks, respectively, in order to observe the effect of this medication in correlation with the duration of administration. Both fenofibrate and simvastatin decrease bone strength, and the effect was more significant with the increase of the duration of treatment. The negative effects on bone tissue are more significant with fenofibrate.