Pan-cancer analysis of HOMER1 in hepatocellular carcinoma revealing diagnostic potential and immune landscape with experimental validation
Our findings demonstrate that HOMER1 functions as a potential oncogene across multiple cancers and actively promotes malignant phenotypes in hepatocellular carcinoma. This study highlights HOMER1 as a promising prognostic biomarker and therapeutic target, providing new insights into cancer prognosis and immunotherapy strategies.
Authors
- Ziyan Lu (ORCID: https://orcid.org/0000-0003-2901-3801)
- Meifeng Chen (ORCID: https://orcid.org/0000-0002-7170-0843)
- Yongguang Wei (ORCID: https://orcid.org/0000-0002-2482-5619)
- Chuangye Han (ORCID: https://orcid.org/0000-0002-7670-4763)
- Shutian Mo (ORCID: https://orcid.org/0000-0001-9385-0757)
- Guohong Yan (ORCID: https://orcid.org/0000-0002-1978-9393)
- Xuan Wang (ORCID: https://orcid.org/0000-0002-0830-0898)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-9523-5296)
- Xinping Ye (ORCID: https://orcid.org/0000-0002-9200-1312)
- Jiaming Liang (ORCID: https://orcid.org/0009-0000-9137-1605)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1007/s12672-025-03528-6
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00