Quantitative impedance-based characterization of breast cancer cell migration and metastatic potential

This work validates the use of cellular impedance-based assay systems to evaluate multiple cell characteristics. In a single experiment, cell spread, cell proliferation, cell-cell barrier integrity, and 2D cell migration were able to be quantified. These findings parallel previously published data for cell migration of the specific cell lines used, while highlighting the role of leptin in cancer behavior. Overall, the potential for a bioelectronic impedance assay system was demonstrated and its validity in effectively detecting and quantifying cell behaviors was proven.