Molecular interplay between TXNIP and GLUT9 underlies uric acid transport dysregulation in vitro under hyperuricemic stress
TXNIP may influence UA reabsorption in hyperuricemia via ROS-induced upregulation and subsequent enhancement of its expression through interaction with the UA transporter protein, GLUT9, hence impacting the progression of hyperuricemia.
Authors
- Wujin Chen (ORCID: https://orcid.org/0000-0003-0560-8026)
- You‐cai Zhu (ORCID: https://orcid.org/0009-0002-5912-633X)
- Yuping Sun
- Miao‐qiao Du
- Mayina Kahaer
- Yi He (ORCID: https://orcid.org/0000-0002-9367-6186)
- Qingqing Yang
- Bei Zhang (ORCID: https://orcid.org/0000-0002-4602-5524)
- Xiaoyu Chen (ORCID: https://orcid.org/0000-0002-9913-4898)
Institutions
- Xinjiang Medical University (CN)
- Xinjiang Uygur Autonomous Region Institute of Metrology and Measurement (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
- Karamay Central Hospital of Xinjiang (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s40001-025-03209-8
- Citations
- 2
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 2.86