Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study
This study identifies key plasma proteins with potential causal roles in BP regulation and CVD risk, highlighting BP as a major mediator of their effects on CAD and stroke. These findings provide novel insights into the molecular mechanisms underlying hypertension-related CVD and identify promising protein targets for further investigation.
Authors
- James Yarmolinsky (ORCID: https://orcid.org/0000-0003-4371-0873)
- Manuel Mayr (ORCID: https://orcid.org/0000-0002-0597-829X)
- Alexander Smith (ORCID: https://orcid.org/0000-0001-6418-613X)
- Marie‐Joe Dib (ORCID: https://orcid.org/0000-0001-7591-5684)
- Charalabos Antonatos (ORCID: https://orcid.org/0000-0002-5967-9367)
- Ioanna Tzoulaki (ORCID: https://orcid.org/0000-0002-4275-9328)
- Paul Elliott (ORCID: https://orcid.org/0000-0002-7511-5684)
- Fotios Koskeridis (ORCID: https://orcid.org/0000-0002-1253-7556)
- Yi-An Ko (ORCID: https://orcid.org/0000-0002-0066-358X)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Devendra Meena
- Jingxian Huang (ORCID: https://orcid.org/0000-0002-8969-8382)
- Xinzhu Yu (ORCID: https://orcid.org/0000-0002-1073-6455)
- Georg Otto (ORCID: https://orcid.org/0000-0002-3929-948X)
- Yiannis Vasilopoulos (ORCID: https://orcid.org/0000-0002-3167-7642)
- Abbas Dehghan (ORCID: https://orcid.org/0000-0001-6403-016X)
- Siwei Wu
Institutions
- University of Patras (GR)
- Academy of Athens (GR)
- Hospital of the University of Pennsylvania (US)
- British Heart Foundation (GB)
- Lung Institute (US)
- UK Dementia Research Institute (GB)
- Imperial College London (GB)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1093/eurheartj/ehaf725
- Citations
- 4
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 7.27