A novel lncRNA-mediated signaling axis governs cancer stemness and splicing reprogramming in hepatocellular carcinoma with therapeutic potential
Our study reveals a novel lncRNA-mediated signaling axis that integrates transcriptional regulation and splicing reprogramming to sustain cancer stemness and progression in HCC. Targeting this axis offers promising therapeutic opportunities for HCC treatment.
Authors
- Xiaoren Zhang (ORCID: https://orcid.org/0000-0003-4080-433X)
- Weifei Liang (ORCID: https://orcid.org/0000-0003-3999-5925)
- Yubin Chen (ORCID: https://orcid.org/0000-0002-9912-7655)
- Ke Si (ORCID: https://orcid.org/0000-0002-1168-5979)
- Lantian Zhang
- Zhanying Wu
- Wenliang Zhang (ORCID: https://orcid.org/0000-0003-0454-6935)
- Zhi‐Yong Wu (ORCID: https://orcid.org/0000-0003-2535-1619)
- Zehang Jiang
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Kingmed Diagnostics (CN)
- Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s13046-025-03546-w
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 2.81