Chrysosplenetin acts as a homeostasis stabilizer with dual-function in shattering Plasmodium berghei K173 resistance to artemisinin driven by both ABC transporters and heme-ROS/GSH axis
The efflux pump function of P-gp is probably not a critical factor in the mechanism by which CHR reverses ART resistance. Instead, CHR acts as a homeostasis stabilizer with dual functions: it disrupts Plasmodium berghei K173 resistance to ART driven by both ABC transporters and the heme-ROS/GSH axis, in which the non-transport function of P-gp on ART is involved.
Authors
- Hongyan Ji (ORCID: https://orcid.org/0000-0002-6388-8049)
- Ruonan Bo
- Jingxuan Tian
- Qingfeng Tan
- Yifan Huang (ORCID: https://orcid.org/0000-0002-6883-9158)
- Hua Gao (ORCID: https://orcid.org/0000-0003-1015-5367)
- Jing Chen (ORCID: https://orcid.org/0000-0003-1581-0025)
- Xin Heng (ORCID: https://orcid.org/0000-0002-1841-0556)
- Xiangyu Wang (ORCID: https://orcid.org/0000-0001-8718-6941)
- Junyi Yang (ORCID: https://orcid.org/0000-0002-0444-4413)
- Linwei Chen (ORCID: https://orcid.org/0000-0003-3676-7812)
- Yutao Huang
Institutions
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1186/s13071-025-07018-0
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ningxia Medical University
- Chengdu University of Traditional Chinese Medicine
- Chengdu University