Cognitive Function and Proteomic Changes in Patients with Autoantibody-Positive Neurodegenerative Dementia
This exploratory study provides preliminary evidence of distinct clinical and molecular signatures in autoantibody-positive neurodegeneration. ARRB1 and CAPN2 may contribute to cognitive resilience in this group, while UGGT1 appears associated with cognitive decline in autoantibody-negative cases. Owing to the limited sample size, these findings should be considered hypothesis-generating and warrant validation in larger, independent cohorts before consideration as biomarkers or therapeutic targets.
Authors
- Cuibai Wei (ORCID: https://orcid.org/0000-0001-6575-2607)
- Xiaodong Han (ORCID: https://orcid.org/0000-0003-4512-3699)
- Wenxian Sun (ORCID: https://orcid.org/0000-0001-6352-2461)
- Chang Xu (ORCID: https://orcid.org/0009-0002-7798-6907)
- Pin Wang (ORCID: https://orcid.org/0000-0002-8031-8494)
- Shaoqi Li (ORCID: https://orcid.org/0000-0001-6571-9145)
- Heya Luan
- Jin Gong
Institutions
- Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- National Clinical Research (US)
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Neurology and Therapy
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1007/s40120-025-00828-5
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49