İNSÜLİN DİRENCİ VE VİTAMİN D EKSİKLİĞİNİN KAN PARAMETRELERİYLE İLİŞKİSİ

Aim: To investigate HOMA-IR and Vitamin D levels in patients complaining of weight gain and to idendify their relationship with blood parameters taken for examination.Materials and Methods: There were a sum of 99 participants in the research (nmale = 25, nfemale = 74). Fasting glucose and insulin, cholesterol, complete blood count, aspartate/alanine transaminase, thyroid stimulating hormone and 25-OH D levels were studied. Two different groups were created in the study. By calculating HOMA IR; those > 2.5 and above were placed in the insulin resistance group, while those < 2.5 were included in the non-insulin resistance group. In the Vit D classification, those with 25 OH D < 20 were categorized as deficient, and those with ≥ 20 OH D were categorized as sufficient. The correlation of the groups with blood parameters regarding these classifications was identified.Results: BMI, ALT TRG, Ferritin, FBG, INSULIN, HBG and HCT values were significantly higher in Insulin Resistance group, while HDL values were lower (p < 0.05). Positive correlation was noticed between HOMA IR and MPV (p=0.289; p=0.04). BMI was significantly higher and a significant negative correlation was observed with FBG and TSH in VitD deficiency group (p < 0.05). Conclusion:HOMA IR was associated with increased BMI and fasting glucose in both groups with >2.5 and 25 OH D