β-Cell Mass in Individuals With and Without Postbariatric Hypoglycemia After Roux-en-Y Gastric Bypass
The exact mechanism of postbariatric hypoglycemia (PBH) is unclear, but β-cell mass expansion is hypothesized to play a role. We used [68Ga]Ga-NODAGA-exendin-4 positron emission tomography/computed tomography (PET/CT) to determine β-cell mass in individuals with and without PBH after Roux-en-Y gastric bypass surgery. β-Cell mass did not differ between individuals with and without PBH. Pancreas volume was lower in individuals with PBH compared with those without PBH. Our data argue against β-cell mass expansion to explain PBH after Roux-en-Y gastric bypass. Further study is required to understand PBH.
Authors
- Cees J. Tack (ORCID: https://orcid.org/0000-0003-0322-1653)
- Rick I. Meijer (ORCID: https://orcid.org/0000-0002-5360-5439)
- Arianne C. van Bon (ORCID: https://orcid.org/0009-0003-9459-8321)
- Laura N. Deden (ORCID: https://orcid.org/0000-0002-1243-5111)
- Martin Gotthardt (ORCID: https://orcid.org/0000-0002-6537-7744)
- Eric J. Hazebroek (ORCID: https://orcid.org/0000-0001-5458-3334)
- Bastiaan E. de Galan (ORCID: https://orcid.org/0000-0002-1255-7741)
- Sevilay Tokgöz (ORCID: https://orcid.org/0009-0009-7597-8170)
- Marti Boss (ORCID: https://orcid.org/0000-0002-5837-1803)
- Hans de Boer (ORCID: https://orcid.org/0000-0003-3516-8914)
- Adrianne Hofboer
Institutions
- Radboud University Nijmegen (NL)
- Maastricht University Medical Centre (NL)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- Netherlands Heart Institute (NL)
- Rijnstate Hospital (NL)
Publication Details
- Journal
- Diabetes
- Published
- 2025-10-09
- DOI
- https://doi.org/10.2337/db25-0572
- Primary Topic
- Bariatric Surgery and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Radboud Universiteit
- Radboud Universitair Medisch Centrum