Yağda çözünen postbiyotiklerle yeni mikrobiyom dostu temizleyici yağ formülasyonu

Objective: In recent years, the field of preventive cosmetic care has gained importance alongside the established effectiveness of nutrition in preventing diseases. Within the scope of this preventive approach, the microbiota has been a focal point in numerous studies, with its state being associated with a range of health concerns, including inflammation, metabolic diseases, dermatological diseases, and neurodegenerative diseases.The present study aims to investigate the positive effects of a cleanser formulated with a postbiotic raw material dissolved in oil on skin microbiota and cells. In this study, the skin cleansing oil containing 2% postbiotic LTO 35 was utilised as a skin microbiota simulation (Lactobacillus crispatus LTC-KC24011, Staphylococcus epidermidis ATA-LSE 0198052) and normal keratinocytes (HEKA 500K CELL), Staphylococcus aureus ATA-LTCA 011204, Staphylococcus capitis ATA-LSC 0201201, Propionibacterium acnes ATA-LPC 0204221, Streptococcus pyogenes ATA-TCSP 210911, and Candida albicans ATA-LTCA 0504212. The results demonstrated that the cleanser did not cause harm to keratinocytes, maintained microbiota balance, and promoted cellular repair.The objective of this study was to investigate the positive effects of a cleanser made using oil-solubilised postbiotic raw material on skin microbiota and cells.Material&Method: In this study, a skin cleansing oil containing 2% postbiotic LTO 35 was utilised to simulate normal keratinocytes (HEKA 500K CELL) and skin microbiota (Lactobacillus crispatus LTC-KC24011, Staphylococcus epidermidis ATA-LSE 0198052, Staphylococcus aureus ATA -LTCA 011204, Staphylococcus capitis ATA-LSC 0201201, Propionibacterium acnes ATA-LPC 0204221, Streptococcus pyogenes ATA TCSP 210911, Candida albicans ATA-LTCA 0504212. The bacteria utilised in the simulation and the postbiotic employed in the formulation (LTO 35 Streptococcus thermophilus ATA-LTC St140700, Bifidobacterium animalis ATA-BSLA0310, Lactobacillus acidophilus ATA-LAP1201 ferment extract in oil lysate) were obtained from the ATA BIO Technology culture collection. The simulation contact time was applied as 1 hour.Results: The Purifying Oil Cleanser with Postbiotics sample examined in this study was found to be microbiologically suitable. The equilibrium test yielded a positive result, and it was observed that the sample did not change in the direction of pathogens. According to the analyses, it can be concluded that the Purifying Oil Cleanser with Postbiotics sample does not harm the diversity of skin microbiota and is microbiome-friendly.Conclusion: Upon evaluation of the results, it was observed that the substance did not cause harm to keratinocytes, it maintained microbiota balance, and it promoted cellular repair.