Four-factor nomogram for early-onset sepsis in preterm neonates: Development and internal validation of a stewardship tool

A four-factor nomogram using EMR-available variables accurately stratifies EOS risk in preterm infants and may support risk-based antibiotic decisions while limiting overtreatment. Prospective multicenter external validation is warranted to confirm generalizability and guide implementation.

Authors

Cuncun Shen (ORCID: https://orcid.org/0000-0002-7318-5427)
Huifen Chen (ORCID: https://orcid.org/0009-0005-9443-3345)
Li Guo (ORCID: https://orcid.org/0000-0002-6985-1239)
Haotian Zhao (ORCID: https://orcid.org/0000-0003-2315-8452)
Chunhui Zhao
Zhiyang Zhang (ORCID: https://orcid.org/0009-0004-4057-7098)

Institutions

Hebei Medical University (CN)
Fourth Hospital of Hebei Medical University (CN)
Hebei General Hospital (CN)
First Hospital of Shijiazhuang (CN)

Publication Details

Journal: PLoS ONE
Published: 2025-10-09
DOI: https://doi.org/10.1371/journal.pone.0334342
Primary Topic: Neonatal and Maternal Infections
Type: article
Field-Weighted Citation Impact: 0.00

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article

Four-factor nomogram for early-onset sepsis in preterm neonates: Development and internal validation of a stewardship tool

Cuncun Shen, Huifen Chen, Li Guo, Haotian Zhao et al.

Oct 9, 2025

PLoS ONE

Neonatal and Maternal Infections

article

Four-factor nomogram for early-onset sepsis in preterm neonates: Development and internal validation of a stewardship tool

Cuncun Shen, Huifen Chen, Li Guo, Haotian Zhao, Chunhui Zhao, Zhiyang Zhang

October 9, 2025article en

Abstract

A four-factor nomogram using EMR-available variables accurately stratifies EOS risk in preterm infants and may support risk-based antibiotic decisions while limiting overtreatment. Prospective multicenter external validation is warranted to confirm generalizability and guide implementation.

PLoS ONEVol. 20(10)

Hebei Medical University (CN), Fourth Hospital of Hebei Medical University (CN), Hebei General Hospital (CN), First Hospital of Shijiazhuang (CN)

Openalex Percentile: Top 62%

Neonatal and Maternal Infections

DOI Open Access PDF OpenAlex

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Four-factor nomogram for early-onset sepsis in preterm neonates: Development and internal validation of a stewardship tool — Cuncun Shen, Huifen Chen, et al. · PLoS ONE (2025) | TGRS Research Map | TGRS