Metabolic syndrome, social isolation, and sarcopenia in mild cognitive impairment: A multifaceted analysis of risk factors and mediating pathways

Metabolic disorders, social isolation, and sarcopenia increase the risk of MCI through independent and synergistic effects, which are partially mediated by lipid metabolism pathways. A multidimensional strategy integrating metabolic management, social support, and muscle strength intervention needs to be developed for high-risk populations such as elderly individuals and rural women.