Caveolin-1 knockout improves CFA-induced inflammatory pain in adult mice through modulating the cGAS STING pathway and autophagy
This study reveals a novel role of Cav1 in inflammatory pain, demonstrating its regulation of inflammation through modulation of the cGAS-STING pathway and autophagy. These findings advance our understanding of the pathogenesis of inflammatory pain and identify Cav1 as a potential therapeutic target.
Authors
- Ning Zheng (ORCID: https://orcid.org/0000-0003-3503-8167)
- Ching‐Lan Cheng (ORCID: https://orcid.org/0000-0002-7201-8491)
- Xiaocheng Zhu (ORCID: https://orcid.org/0000-0001-9600-0862)
- Fan Zhang (ORCID: https://orcid.org/0000-0002-1256-3818)
- Huan Chang (ORCID: https://orcid.org/0009-0000-1362-0557)
- Hui Yang (ORCID: https://orcid.org/0000-0002-3938-9530)
- Haiyan Zhu (ORCID: https://orcid.org/0000-0003-2973-0018)
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1371/journal.pone.0333646
- Citations
- 1
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81