Discovering subtypes with imaging signatures in the Motoric Cognitive Risk Syndrome Consortium using weakly supervised clustering
Different patterns of brain atrophy were observed among the people with moderate and slow gait speedsSlower gait speeds were associated with substantial cortical atrophy, higher rates of Motoric Cognitive Risk Syndrome (MCR), and worse cognitive performanceThis approach can aid patient stratification at early asymptomatic stages and have implications for precision health.
Authors
- Hiroyuki Shimada
- Ali Ezzati (ORCID: https://orcid.org/0000-0003-1307-4589)
- Olivier Beauchet (ORCID: https://orcid.org/0000-0003-2534-4830)
- Takehiko Doi (ORCID: https://orcid.org/0000-0003-0205-8663)
- Michele L. Callisaya (ORCID: https://orcid.org/0000-0003-2122-1622)
- Bhargav Teja Nallapu (ORCID: https://orcid.org/0000-0001-6368-8509)
- Richard Beare (ORCID: https://orcid.org/0000-0002-7530-5664)
- Emmeline Ayers (ORCID: https://orcid.org/0000-0002-5061-3708)
- Kellen K. Petersen (ORCID: https://orcid.org/0000-0003-3195-3456)
- Helena M. Blumen (ORCID: https://orcid.org/0000-0002-0275-6616)
- Velandai Srikanth (ORCID: https://orcid.org/0000-0002-8442-8981)
- Sofiya Milman (ORCID: https://orcid.org/0000-0001-9247-0082)
- Sandra Aleksić (ORCID: https://orcid.org/0000-0001-9255-1392)
- V G Pradeep Kumar
- Richard Lipton
- Joe Verghese
Institutions
- University of Tasmania (AU)
- Albert Einstein College of Medicine (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of California, Irvine Medical Center (US)
- Stony Brook Medicine (US)
- Institut Universitaire de Gériatrie de Montréal (CA)
- UC Irvine Health (US)
- Baby Memorial Hospital (IN)
- Murdoch Children's Research Institute (AU)
- National Center for Geriatrics and Gerontology (JP)
- Monash University (AU)
- Stony Brook University (US)
- Université de Montréal (CA)
- Delft University of Technology (NL)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70197
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Amgen
- Teva Pharmaceutical Industries
- Cure Alzheimer's Fund
- National Institutes of Health
- National Institute on Aging