Recovery of Renal Function and Late Withdrawal of Hemodialysis in IgD Multiple Myeloma: A Case Report

IgD multiple myeloma (MM) is a rare and aggressive subtype often associated with advanced-stage diagnosis and dialysis-dependent renal failure, with late renal recovery remaining unpredictable. We report the first documented case of a 56-year-old patient with stage III-B IgD λ-MM who achieved dialysis independence 1,260 days post-diagnosis, the longest delay reported to date. A robust hematological response to bortezomib-based induction and lenalidomide maintenance enabled progressive renal improvement. This case highlights the potential for delayed renal recovery and underscores the importance of coordinated hematology-nephrology care in managing advanced IgD-MM.