Predicting Spaceflight-Associated Neuro-Ocular Syndrome in International Space Station Astronauts
In this cohort study, SANS cases from previous LDSF were highly likely to be diagnosed with SANS in subsequent LDSF missions and vice versa, while SANS ODE severity appeared remarkably similar across LDSF missions for individual eyes. To our knowledge, these findings represent the first and only reliable forecast for SANS, permitting precise in-flight treatment and prevention strategies to be tailored for individual astronauts in subsequent LDSF missions, even before launch.
Authors
- Thomas Oswald (ORCID: https://orcid.org/0009-0001-6333-058X)
- Chandrika Gibson (ORCID: https://orcid.org/0000-0002-1147-6608)
- William J. Tarver (ORCID: https://orcid.org/0000-0003-0370-9157)
- Andrew G Lee
- Nimesh B. Patel (ORCID: https://orcid.org/0000-0002-1772-2611)
- Thomas H. Mader (ORCID: https://orcid.org/0000-0002-3956-8934)
- Sara S. Mason
- Tyson Brunstetter
- Ann Tsung
- David M. Brown (ORCID: https://orcid.org/0000-0002-2570-5766)
- Sue Osborne
- Millennia Young
Institutions
- KBR (United States) (US)
- AEgis Technologies (United States) (US)
- Methodist Hospital (US)
- Retina Consultants of Texas (US)
- South Shore Eye Care (US)
- Johnson Space Center (US)
- University of Houston (US)
Publication Details
- Journal
- JAMA Ophthalmology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1001/jamaophthalmol.2025.3406
- Primary Topic
- Spaceflight effects on biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00