Pathogenic Variants, Family History, and Cumulative Risk of Breast Cancer in US Women
In this study, population-based estimates of cumulative breast cancer risk for established PVs, as informed by the CARRIERS case-control sample, varied by family history and potentially modifiable risk factors. These estimates provide guidance for identifying individuals who will most benefit from enhanced screening and prevention strategies.
Authors
- Chunling Hu (ORCID: https://orcid.org/0000-0002-6814-4639)
- Amy Trentham‐Dietz (ORCID: https://orcid.org/0000-0002-5971-4660)
- Song Yao
- A. Heather Eliassen (ORCID: https://orcid.org/0000-0002-3961-6609)
- Alpa V. Patel (ORCID: https://orcid.org/0000-0001-9997-1218)
- Fergus J. Couch (ORCID: https://orcid.org/0000-0001-9417-9985)
- Jack A. Taylor (ORCID: https://orcid.org/0000-0001-5303-6398)
- Alexander P. Keil (ORCID: https://orcid.org/0000-0002-0955-6107)
- Kathryn J. Ruddy (ORCID: https://orcid.org/0000-0001-6298-332X)
- Jeffrey N. Weitzel (ORCID: https://orcid.org/0000-0001-6714-092X)
- Eric C. Polley (ORCID: https://orcid.org/0000-0002-5152-8740)
- Sara Lindströem
- Clara Bodelón (ORCID: https://orcid.org/0000-0002-6578-2678)
- Christine B. Ambrosone (ORCID: https://orcid.org/0000-0003-1717-9943)
- James M. Hodge (ORCID: https://orcid.org/0000-0002-6253-7394)
- Kristen D. Brantley (ORCID: https://orcid.org/0000-0003-0084-4775)
- Peter Kraft (ORCID: https://orcid.org/0000-0002-4472-8103)
- Gary Zirpoli (ORCID: https://orcid.org/0000-0003-1417-5349)
- Katie M. O’Brien (ORCID: https://orcid.org/0000-0002-1931-1349)
- Dale P. Sandler (ORCID: https://orcid.org/0000-0002-6776-0018)
- Paul Livermore Auer (ORCID: https://orcid.org/0000-0003-1735-8044)
- Susan L. Neuhausen (ORCID: https://orcid.org/0000-0001-5053-0390)
- Susan M. Domchek (ORCID: https://orcid.org/0000-0002-5914-7272)
- Celine M. Vachon
- Katherine L. Nathanson (ORCID: https://orcid.org/0000-0002-6740-0901)
- Hoda Anton Culver
- Siddhartha Yadav (ORCID: https://orcid.org/0000-0003-4630-9903)
- Nicholas Boddicker (ORCID: https://orcid.org/0000-0002-6784-2072)
- Elizabeth S. Burnside (ORCID: https://orcid.org/0000-0002-6600-435X)
- Christopher G. Scott (ORCID: https://orcid.org/0000-0003-1340-0647)
- Janet E. Olson (ORCID: https://orcid.org/0000-0003-4944-7789)
- Julie R. Palmer (ORCID: https://orcid.org/0000-0002-6534-335X)
- Fei Chen (ORCID: https://orcid.org/0000-0002-6988-492X)
- Christopher A. Haiman
- James V. Lacey (ORCID: https://orcid.org/0000-0002-4560-8592)
- Kathryn L. Penney
- Lauren R. Teras
- Maria Elena Martinez
- Clarice Ring Weinberg (ORCID: https://orcid.org/0000-0002-7713-8556)
Institutions
- Boston University (US)
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- American Cancer Society (US)
- Roswell Park Comprehensive Cancer Center (US)
- City Of Hope National Medical Center (US)
- Mayo Clinic (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Chicago Department of Public Health (US)
- Breast Cancer Research Foundation (US)
- University of Washington (US)
- University of California, Irvine (US)
- Medical College of Wisconsin (US)
- University of California San Diego (US)
- University of Chicago (US)
- Fred Hutch Cancer Center (US)
- National Institute of Environmental Health Sciences (US)
- University of Wisconsin Carbone Cancer Center (US)
- City of Hope (US)
- Dana-Farber Cancer Institute (US)
- University of Kansas Medical Center (US)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- Division of Cancer Epidemiology and Genetics
- University of Pennsylvania (US)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1001/jamaoncol.2025.3875
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00