Risk Factors for Valvulopathy Among Childhood Cancer Survivors
In this case-control study, heart RT, anthracyclines, and platinum agents were associated with increased VHD risk in childhood cancer survivors. Risks from both RT and anthracyclines were amplified with age and follow-up, underscoring the need for long-term cardiac surveillance.
Authors
- Peter Kaatsch (ORCID: https://orcid.org/0000-0002-8565-0832)
- Elisabeth Cardis (ORCID: https://orcid.org/0000-0003-0999-6839)
- Isabelle Aerts (ORCID: https://orcid.org/0000-0002-5213-3353)
- Helena J. H. van der Pal (ORCID: https://orcid.org/0000-0003-2253-2115)
- Claudia E. Kuehni (ORCID: https://orcid.org/0000-0001-8957-2002)
- Gisela Michel (ORCID: https://orcid.org/0000-0002-9589-0928)
- Zsuzsanna Jakab (ORCID: https://orcid.org/0000-0002-5410-1187)
- Raoul C. Reulen (ORCID: https://orcid.org/0000-0002-7328-0467)
- Roderick Skinner (ORCID: https://orcid.org/0000-0002-1162-675X)
- Fabiën N. Belle (ORCID: https://orcid.org/0000-0002-0037-4817)
- Brice Fresneau (ORCID: https://orcid.org/0000-0001-7603-7828)
- Giao Vu‐Bezin (ORCID: https://orcid.org/0000-0002-9553-0527)
- Elvira C van Dalen (ORCID: https://orcid.org/0000-0002-8886-6532)
- Jop C. Teepen (ORCID: https://orcid.org/0000-0002-2647-2677)
- D. Winter (ORCID: https://orcid.org/0000-0002-1597-4081)
- Nadia Haddy (ORCID: https://orcid.org/0000-0001-9316-8280)
- Boris Schwartz (ORCID: https://orcid.org/0000-0003-1074-7266)
- Florent de Vathaire (ORCID: https://orcid.org/0000-0002-8374-9281)
- Lorna Zadravec Zaletel (ORCID: https://orcid.org/0000-0002-4423-0276)
- Carlotta Sacerdote (ORCID: https://orcid.org/0000-0002-8008-5096)
- Rodrigue S. Allodji (ORCID: https://orcid.org/0000-0002-1895-8415)
- Monica Terenziani (ORCID: https://orcid.org/0000-0002-7080-6718)
- Ibrahima Diallo (ORCID: https://orcid.org/0000-0002-8272-8817)
- Julianne Byrne (ORCID: https://orcid.org/0000-0002-1070-3004)
- Edit Bárdi (ORCID: https://orcid.org/0000-0001-7424-6255)
- G. Levitt
- Lars Hjorth (ORCID: https://orcid.org/0000-0002-8302-7174)
- Elizabeth A. M. Feijen (ORCID: https://orcid.org/0000-0001-8930-3160)
- Momcilo Jankovic (ORCID: https://orcid.org/0000-0001-9773-0576)
- Cécile M. Ronckers (ORCID: https://orcid.org/0000-0003-3524-4657)
- Cristina Veres (ORCID: https://orcid.org/0000-0002-6583-0334)
- Isabelle Thierry-Chef (ORCID: https://orcid.org/0000-0001-6304-2783)
- Desiree Grabow (ORCID: https://orcid.org/0000-0002-4853-3303)
- Francesca Bagnasco (ORCID: https://orcid.org/0000-0003-1601-9518)
- Véronique Minard-Colin
- Leontien C. M. Kremer (ORCID: https://orcid.org/0000-0002-7619-7845)
- Mike Hawkins
- Neige Journy
- Rivalin Aho Glele
Institutions
- University of Bern (CH)
- Johannes Kepler University of Linz (AT)
- University of Ljubljana (SI)
- Inserm (FR)
- University of Lucerne (CH)
- Universitat Pompeu Fabra (ES)
- Lund University (SE)
- Johannes Gutenberg University Mainz (DE)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Royal Victoria Infirmary (GB)
- University Hospital of Bern (CH)
- Instituto de Salud Carlos III (ES)
- Istituto Giannina Gaslini (IT)
- Institut Gustave Roussy (FR)
- Institute of Oncology Ljubljana (SI)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Azienda Ospedaliera San Gerardo (IT)
- Department of Medical Sciences (RU)
- Laboratoire d'études sur les monothéismes (FR)
- St Anna Children's Hospital (AT)
- Princess Máxima Center (NL)
- Institute of Social and Preventive Medicine (CH)
- Skåne University Hospital (SE)
- Great North Children's Hospital (GB)
- Markusovszky Egyetemi Oktatókórház (HU)
- Barcelona Institute for Global Health (ES)
- Piedmont Reference Center for Epidemiology and Cancer Prevention (IT)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- CURE Childhood Cancer (US)
- Boyne Research Institute (IE)
- NIHR Birmingham Biomedical Research Centre (GB)
- Newcastle University (GB)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-10-09
- DOI
- https://doi.org/10.1001/jamaoncol.2025.3863
- Citations
- 3
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 4.16